Journal
JOURNAL OF LIGHTWAVE TECHNOLOGY
Volume 35, Issue 16, Pages 3354-3359Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JLT.2017.2659778
Keywords
Bragg gratings; biosensors; microfibers; Optical fiber sensors
Funding
- Natural Science Young Foundation of Shanxi Province [201601D021024]
- Open Fund of Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications (Jinan University)
- Guangdong Youth Science and Technology Innovation Talents of China [2014TQ01X539]
- Guangdong Natural Science Foundation of China [2014A030313387]
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A reflective fiber-optic biosensor based on microfiber Bragg grating (mFBG) for DNA hybridization detection using layer-by-layer self-assembly technology is demonstrated. By searching the wavelength separation of two well-defined resonances of mFBG in reflection, temperature-compensated refractive index measurement has been achieved. With the help of poly(ethylenimine) (PEI), poly(acrylic acid) (PAA), and single-stranded DNA (ssDNA) for the preparation of a polyelectrolyte multilayer film, more target DNA chains are absorbed by the (PEI/PAA)(4) (PEI/DNA)(1) multilayer films immobilized on the surface of mFBG. The hybridization processes of the target ssDNA with the concentration of 1 mu M have been monitored in real-time together with high specificity of the noncomplementary DNA target.
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