Journal
NEUROIMAGE-CLINICAL
Volume 24, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2019.102019
Keywords
Tractography; Diffusion-weighted MRI; Connectome; Angular gyrus; Insomnia disorder; Reactivity
Categories
Funding
- Bial Foundation [253/12, 190/16]
- Netherlands Organisation of Scientific Research (NWO) [VICI-453.07.001]
- Netherlands Organisation for Health Research and Development (ZonMw) Neuropsychoanalysis Fund [16.561.0001]
- European Research Council [671084 INSOMNIA]
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Insomnia Disorder (ID) is a prevalent and persistent condition, yet its neural substrate is not well understood. The cognitive, emotional, and behavioral characteristics of ID suggest that vulnerability involves distributed brain networks rather than a single brain area or connection. The present study utilized probabilistic diffusion tractography to compare the whole-brain structural connectivity networks of people with ID and those of matched controls without sleep complaints. Diffusion-weighted images and Tl-weighed images were acquired in 51 people diagnosed with ID (21-69 years of age, 37 female) and 48 matched controls without sleep complaints (22-70 years of age, 31 female). Probabilistic tractography was performed to construct the whole-brain structural connectivity network of each participant. Case-control differences in connectivity strength and network efficiency were evaluated with permutation tests. People with ID showed structural hyperconnectivity within a subnetwork that spread over frontal, parietal, temporal, and subcortical regions and was anchored at the right angular gyrus. The result was robust across different edge-weighting strategies. Moreover, converging support was given by the finding of heightened right angular gyrus nodal efficiency (harmonic centrality) across varying graph density in people with ID. Follow-up correlation analyses revealed that subnetwork connectivity was associated with self-reported reactive hyperarousal. The findings demonstrate that the right angular gyrus is a hub of enhanced structural connectivity in ID. Hyperconnectivity within the identified subnetwork may contribute to increased reactivity to stimuli and may signify vulnerability to ID.
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