Journal
SCIENTIA PHARMACEUTICA
Volume 87, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/scipharm87040033
Keywords
cyclodextrins; drug delivery systems; biological barriers; nanopharmaceutics
Categories
Funding
- Hungarian Academy of Sciences [BO/00290/16]
- National Research, Development and Innovation Office, Budapest, Hungary [FK_17 (FK124634)]
- New National Excellence Program of the Ministry of Human Capacities [EFOP-3.6.1-16-2012, UNKP-18-4, UNKP-18-4-DE-99]
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Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological barriers. In this review the most important properties of cyclodextrins and cyclodextrin-based drug delivery systems are summarized with special focus on their biological activity.
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