Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 137, Issue 8, Pages 1609-1611Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2017.04.004
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Funding
- National Institutes of Health [R21AR066505, 1R01AR056666]
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Hannen et al. report that cutaneous glucocorticoidogenesis and expression of glucocorticoid receptors are inhibited in psoriatic skin. These findings substantiate the previous concept that deficient feedback of local proopiomelanocortin and glucocorticoids on cutaneous immunity contributes to inflammatory and autoimmune dermatoses. Restoration of efficient endogenous glucocorticoid signaling represents a realistic goal in treating psoriasis.
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