Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 137, Issue 2, Pages 288-294Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2016.08.013
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Funding
- NIH [K08AR063729 05]
- Duke Cancer Institute as part of the Cancer Center [P30CA014236]
- Duke Skin Disease Research Center [P30AR066527 02]
- Pinnell Center for Investigative Dermatology and Skin Disease Research Center at Duke University Medical Center
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Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutaneous T cells to regulate skin-specific environmental threats, including microbes, injuries, solar UV radiation, and allergens. Since much of this knowledge has been advanced from murine studies, we focus our review on how the mouse state has informed the human state, emphasizing the key parallels and differences.
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