Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/jpm9040049
Keywords
microneedles; medical devices; paediatrics
Funding
- Norte2020 Funding Program
- N2020-PE-Nanothechnology-Based Functional Solutions (NBFS) project [NORTE-01-0145-FEDER-000019]
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Microneedles (MNs) have been extensively explored in the literature as a means to deliver drugs in the skin, surpassing the stratum corneum permeability barrier. MNs are potentially easy to produce and may allow the self-administration of drugs without causing pain or bleeding. More recently, MNs have been investigated to collect/assess the interstitial fluid in order to monitor or detect specific biomarkers. The integration of these two concepts in closed-loop devices holds the promise of automated and minimally invasive disease detection/monitoring and therapy. These assure low invasiveness and, importantly, open a window of opportunity for the application of population-specific and personalised therapies.
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