Journal
MATHEMATICAL MODELLING OF NATURAL PHENOMENA
Volume 14, Issue 2, Pages -Publisher
EDP SCIENCES S A
DOI: 10.1051/mmnp/2018060
Keywords
Lipschitz stability estimate; Carleman estimate; cardiac electrophysiology; bidomain system; physiological ionic model; ionic parameters
Categories
Funding
- EPICARD cooperative research program - INRIA international laboratory LIRIMA
- Tunisian Ministry of Higher Education, Scientific Research and Technology
- French Government [ANR-10-IAHU-04]
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In this paper, we consider an inverse problem of determining multiple ionic parameters of a 2 x 2 strongly coupled parabolic-elliptic reaction-diffusion system arising in cardiac electrophysiology modeling. We use the bidomain model coupled to an ordinary differential equation (ODE) system and we consider a general formalism of physiologically detailed cellular membrane models to describe the ionic exchanges at the microscopic level. Our main result is the uniqueness and a Lipschitz stability estimate of the ion channels conductance parameters of the model using subboundary observations over an interval of time. The key ingredients are a global Carleman-type estimate with a suitable observations acting on a part of the boundary.
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