Journal
RESEARCH IN PHARMACEUTICAL SCIENCES
Volume 14, Issue 5, Pages 448-458Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1735-5362.268206
Keywords
Cancer therapy; D-limonene; Niosome; Solubility
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Funding
- Graduate University of Advanced Technology, Kerman, I.R. Iran
- Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran [96076]
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The low solubility of the plant-extracted agent like D-limonene in cancer therapy is a critical problem. In this study, we prepared D-limonene-loaded niosomes (D-limonene/Nio) for cancer therapy through in vitro cytotoxicity assay of HepG2, MCF-7, and A549 cell lines. The niosomal formulation was prepared by film hydration technique with Span (R) 40: Tween (R) 40: cholesterol (35:35:30 molar ratio) and characterized for vesicle distribution size, morphology, entrapment efficiency (EE%), and in vitro release behaviour. The obtained niosomes showed a nanometric size and spherical morphology with EE% about 87 +/- 1.8%. Remarkably prolonged release of D-limonene from niosomes compared to free D-limonene observed. The loaded formulation showed significantly enhanced cytotoxic activity with all three cancer cell lines (HepG2, Macf-7 and A549) at the concentration of 20 mu M. These results indicated that niosome loaded with phytochemicals can be a promising nano-carrier for cancer therapy applications
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