Journal
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
Volume 37, Issue 7, Pages 287-294Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jir.2017.0011
Keywords
trophoblast; placenta; Hofbauer; interferon
Funding
- Burroughs Wellcome Fund
- March of Dimes
- NIH/NICHD [R01HD091218, R01 AI073755, R01 AI104972, P01 AI106695]
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The emerging mosquito-borne virus, Zika virus (ZIKV), has been causally associated with adverse pregnancy and neonatal outcomes, including miscarriage, microcephaly, serious brain abnormalities, and other birth defects indicative of a congenital ZIKV syndrome. In this review, we highlight work from human and animal studies on routes of infection in pregnancy that lead to adverse fetal and neonatal outcomes. A number of innate and adaptive immune mechanisms and signaling molecules that may have key roles in ZIKV infection pathogenesis are discussed along with putative viral entry pathways. A more granular understanding of pathogenesis of ZIKV infection during pregnancy is critical for developing therapeutics and vaccines and mounting a global public health response to limit ZIKV infections. We also report on new therapeutic interventions that have shown success in preclinical studies.
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