Journal
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES
Volume 29, Issue 3, Pages 310-322Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1045389X17704065
Keywords
Polymeric membranes; finite element simulation; hydrogel swelling; microfluidics; micromechanical pore valve; particle separation
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Funding
- Excellence Initiative by the German Federal Government
- Excellence Initiative by the German State Government
- Center for Advancing Electronics Dresden (cfaed) at Technische Universitat Dresden
- Research Training Group DFG [GRK 1865]
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Membranes act as smart structures in respect to their permeation abilities. Control of particle and fluid permeation through a synthetic membrane can be achieved by using different effects like size-exclusion or electromagnetic interactions that occur between the particles and membrane pores. The simulation of controlled permeability provides an insight into the smart behavior of membranes for chemical signal processing, sensing interfaces or lab-on-a-chip devices. In the current work, we model the underlying physical processes on a microfluidic level using the engineer's approach of laminar flow through pipes. Different pore geometries inside a composite membrane system consisting of a polyethylene terephthalate support membrane and a poly(N-isopropylacrylamide) hydrogel-layer are investigated. Simulations for different states of thermally induced pore opening are performed for free and blocked states. From the results we derive paradigms for the design of a membrane system for microfluidic cell-size profiling considering stimulus-range, pore shape and measurement setup.
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