Journal
NANOSCALE
Volume 11, Issue 46, Pages 22237-22242Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nr07334e
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Funding
- National Key Research and Development Program of China [2017FYA0205301]
- National Key Basic Research Program of China [2015CB931802]
- Medical Engineering Cross Project of Shanghai Jiao Tong University [YG2017QN63, YG2017QN27, ZH2018QNA61]
- Startup Fund for Youngman Research at SJTU [18X100040050]
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We developed a versatile and modular method for cytosolic protein delivery through metal ion-induced co-assembly of gold nanoclusters and proteins into supramolecular assemblies. The versatility and high efficiency of this strategy to assemble and deliver various proteins into living cells were demonstrated. Importantly, the activity of proteins was maintained during the delivery. This modular approach provides an exciting and promising new nano-platform for cytosolic protein delivery.
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