Journal
JOURNAL OF INSECT SCIENCE
Volume 17, Issue 2, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jisesa/iex021
Keywords
HMGR; Cantharidin; Epicauta chinensis; Tenebrio molitor; fat body
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Funding
- Special Fund for the Public Interest (Agriculture) [200903052]
- Sci-Tech Innovation Project of Shaanxi Province [2009ZDKG-06, 13115]
- National Natural Science Foundation of China [31101442]
- Fundamental Research Funds for the Central Universities [2452015113, 2452013QN044]
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Cantharidin, a terpenoid defensive toxin mainly produced by blister beetles, is among the most widely known insect natural products in the world. However, little is known about the site of cantharidin biosynthesis in vivo. Our previous research showed that 3-hydroxy-3-methylglutary-CoA reductase (HMGR) is an essential enzyme in cantharidin biosynthesis. In this report, we further investigated cantharidin titer and HMGR mRNA expression levels in different tissues of male and female Epicauta chinensis, and performed a comparative analysis of HMGR transcript levels in male Tenebrio molitor, a Tenebrionidae beetle that cannot produce cantharidin. HMGR transcripts had a positive correlation with cantharidin production. Furthermore, the specifically high amounts of HMGR transcript and abundant cantharidin production in fat body of male E. chinensis indicated the process of cantharidin synthesis may occur in the fat body.
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