Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 177, Issue -, Pages 127-137Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2017.09.020
Keywords
Iridium; Cyclometalated; DNA condensation; Non-viral vector; Fluorescent
Funding
- Science and Engineering Research Board, Department of Science and Technology, New Delhi, India [YSS/2014/000546]
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Two phosphorescent cyclometalated iridium(III)-triptycenyl-1,10-phenanthroline complexes [Ir(PPY)(2)(tptphen)](+) (1) and [Ir(bhq)(2)(tpt-phen)](+) (2) {ppy = 2-phenylpyridine, bhq = Benzo[h]quinoline, tpt-phen = -triptycenyl-1,10-phenanthroline} have been synthesized and structurally characterized. The structure of complex 2 has been studied by single crystal X-ray crystallography. The photophysical properties of complexes in a different solvent have also been investigated. The binding of complexes to the double stranded calf thymus (CT-DNA) has been investigated by spectroscopic techniques. These complexes condense originally circular plasmid DNA into particulate structures. The DNA-condensation induced by these complexes have been investigated by electrophoretic mobilty shift assay, dynamic light scattering, and fluorescence microscopy. Furthermore, the cytotoxicity of these complexes towards HeLa cells have been studied and their cellular localisation properties have been investigated by fluorescence microscopy.
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