Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 173, Issue -, Pages 141-143Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2017.05.008
Keywords
Porphyrin derivative; Z-DNA; Circular dichroism; B-Z transition; Chiroptical probe; Supramolecular chemistry
Funding
- MIUR - FIRB [RBFR12WB3W]
- MIUR - FIR [48C43B]
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In this work we have designed a new zinc(II) porphyrin with four spermines conjugate in the meso positions, meso-tetrakis-(4-carboxysperminephenyl)porphyrin, ZnTCPPSpm4) with the aim of acting as a chiroptical probe for the Z-form of DNA, a high energy transient conformation of DNA. In addition to monitor by Electronic Circular Dichroism chiroptical response the formation of Z-DNA in the presence of micromolar concentration of spermine, this porphyrin based molecular probe is also able to catalyze and stabilize this important DNA structure. The ZnTCPPSpm4 conjugate represents a perfect example of single molecule, which possesses all these three properties at the same time. The increased stability of Z-DNA in the presence of this derivative opens possibility for further studies on the mechanism of B-to Z-DNA transition, and on the design of new probes with improved efficiency.
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