Journal
JOURNAL OF INNATE IMMUNITY
Volume 9, Issue 3, Pages 250-261Publisher
KARGER
DOI: 10.1159/000455857
Keywords
Pseudomonas aeruginosa; Inflammation; Inflammasome; Pneumonia; Innate immunity; Host defense
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Funding
- NIAID NIH HHS [R01 AI081825] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007205] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI081825] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007205] Funding Source: NIH RePORTER
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The Gram-negative opportunistic pathogen Pseudomonas aeruginosa exploits failures of barrier defense and innate immunity to cause acute infections at a range of anatomic sites. We review the defense mechanisms that normally protect against P. aeruginosa pulmonary infection, as well as the bacterial products and activities that trigger their activation. Innate immune recognition of P. aeruginosa is critical for pathogen clearance; nonetheless, inflammation is also associated with pathogen persistence and poor host outcomes. We describe P. aeruginosa adaptations that improve this pathogen's fitness in the inflamed airway, and briefly discuss strategies to manipulate inflammation to benefit the host. Such adjunct therapies may become increasingly important in the treatment of acute and chronic infections caused by this multi-drug-resistant pathogen. (C) 2017 S. Karger AG, Basel
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