Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 215, Issue -, Pages S96-S102Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw423
Keywords
dengue; flavivirus; dengue drug discovery; antivirals; dengue prophylaxis; dengue therapeutics
Categories
Funding
- National Health and Medical Research Council of Australia
- Queensland State Government
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Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue.
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