Journal
FEMS MICROBIOLOGY LETTERS
Volume 366, Issue 21, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnz246
Keywords
Trichoderma; emerging mycoses; agricultural environments; multilocus phylogenetic analysis; azole resistance; GCPSR concept; Trichoderma longibrachiatum f. sp. bissettii nom. prov.
Categories
Funding
- Hungarian Scientific Research Fund [K-116475]
- Szechenyi 2020 Programme [GINOP-2.2.1-15-2016-00006]
- COST action HUPLANT-control (Control of Human Pathogenic Micro-organisms in Plant Production Systems) [CA16110]
- Austrian Science Foundation (FWF) [P25613-B20]
- Janos Bolyai Research Scholarship (Hungarian Academy of Sciences)
- Bolyai Plus Scholarship (New National Excellence Programme)
Ask authors/readers for more resources
Trichoderma species are abundant in different agricultural habitats, but some representatives of this genus, mainly clade Longibrachiatum members are also emerging as causative agents of various human diseases with even fatal outcome. Strains of these species frequently show resistance to commonly used azole antifungals. Based on previous data it is hypothesized that Trichoderma isolates identified in human infections derive from environmental-including agricultural-origins. We examined Trichoderma longibrachiatum Rifai and Trichoderma bissettii Sandoval-Denis & Guarro strains recovered from four novel cases of human mycoses, along with isolates from previous case reports and different agricultural habitats, using multilocus phylogenetic analysis, BIOLOG Phenotype Microarrays and Etest. Strains attributed to T. bissettii were more abundant in both clinical and agricultural specimens compared to T. longibrachiatum. The majority of the isolates of both taxa could tolerate >256, >32 and >32 mu g/ml fluconazole, itraconazole and posaconazole, respectively. None of the obtained results revealed characteristic differences between strains of clinical and agricultural origin, nor between the two taxa, supporting that agricultural environments may be significant sources of infections caused by these emerging human fungal pathogens. Furthermore, based on our findings we propose the re-classification of T. bissettii as T. longibrachiatum f. sp. bissettii.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available