Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 215, Issue 8, Pages 1264-1269Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix095
Keywords
HIV-associated cardiovascular disease; arterial inflammation; atherosclerosis
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Funding
- Navidea Biopharmaceuticals
- National Institutes of Health (NIH from the National Center for Research Resources) [R01NS40237, M01-RR-01066, 1 UL1 RR025758-01, NIH DKP30 045061, R43HL127846]
- Harvard Catalyst/ Harvard Clinical and Translational Sciences Center
- Harvard Catalyst/ Harvard Clinical and Translational Sciences Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH) [8KL2TR000168-05]
- NIH [T32DK 007028, T32EB 013180]
- American Roentgen Ray Society
- NIH through the National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke [U24MH100930, U24MH100928]
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Background. The ability to noninvasively assess arterial CD206(+) macrophages may lead to improved understanding of human immunodeficiency virus (HIV)-associated cardiovascular disease. Methods. We trialed a novel macrophage-specific arterial imaging technique. Results. We demonstrated colocalization between technetium Tc 99m tilmanocept (Tc-99m-tilmanocept) and CD206(+) macrophages ex vivo. In vivo application of Tc-99m-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level Tc-99m-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non-HIV-infected subjects (P =.009). Among all subjects, aortic high-level Tc-99m-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P =.003) on computed tomographic angiography, and this relationship held when we controlled for HIV status. Conclusion. These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV.
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