Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 216, Issue 2, Pages 191-197Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix257
Keywords
Vaccination; Varicella-zoster; inflammation; heart failure; immunosenescence
Categories
Funding
- Labarge Optimal Aging Initiative
- Canadian Institutes of Health Research
- Merck Vaccines
- McMaster Immunology Research Centre
- M. G. DeGroote Institute for Infectious Disease Research
Ask authors/readers for more resources
Background. Elderly long-term care residents often exhibit a myriad of risk factors for immune dysfunction, including chronic inflammation and multiple comorbid conditions, which undoubtedly contribute to their enhanced susceptibility to infection. Hence, understanding the factors required for optimal vaccine responsiveness is critical. Methods. We examined 187 elderly nursing home residents (aged 80-102 years) and 50 community-dwelling seniors (aged 60-75 years) immunized with the live-attenuated varicella-zoster virus (VZV) vaccine. Specifically, we examined whether vaccine responsiveness was associated with serum C-reactive protein (CRP), tumor necrosis factor, interleukin 1 beta, 6, and 10, leukocyte telomere length, chronic disease status, and frailty. Results. Elderly participants had significantly higher levels of CRP, tumor necrosis factor, and interleukin 6 and shorter leukocyte telomere length. Vaccine responsiveness was inversely related to the CRP level in elderly participants, but not seniors, and those with congestive heart failure were less likely to achieve a 2-fold response (odds ratio, 0.08). The latter relationship is probably due to immunosenescence, because heart failure was associated with increased senescent CD4(+) T cells, and reduced naive and effector and central memory CD8(+) T cells. Conclusions. In summary, these data improve our understanding of vaccine responsiveness for those in long-term care, suggesting that certain risk factors are associated with a greater likelihood of vaccine failure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available