Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 51, Issue 12, Pages 1189-1197Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmz121
Keywords
molecular hydrogen; molecular mechanism; antioxidant; anti-inflammation; anti-apoptosis
Categories
Funding
- National Natural Science Foundation of China [81770855]
- Taishan Scholars Foundation of Shandong Province [ts201511057]
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Ever since molecular hydrogen was first reported as a hydroxyl radical scavenger in 2007, the beneficial effect of hydrogen was documented in more than 170 disease models and human diseases including ischemia/reperfusion injury, metabolic syndrome, inflammation, and cancer. All these pathological damages are concomitant with overproduction of reactive oxygen species (ROS) where molecular hydrogen has been widely demonstrated as a selective antioxidant. Although it is difficult to construe the molecular mechanism of hydrogen's biomedical effect, an increasing number of studies have been helping us draw the picture clearer with days passing by. In this review, we summarized the current knowledge on systemic and cellular modulation by hydrogen treatment. We discussed the antioxidative, anti-inflammatory, and anti-apoptosis effects of hydrogen, as well as its protection on mitochondria and the endoplasmic reticulum, regulation of intracellular signaling pathways, and balancing of the immune cell subtypes. We hope that this review will provide organized information that prompts further investigation for in-depth studies of hydrogen effect.
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