Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 217, Issue 7, Pages 1060-1068Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix678
Keywords
Dengue; Zika; flavivirus; arbovirus; laboratory; diagnostics; serology; surveillance
Categories
Funding
- Gates Foundation
- European Union's Research and Innovation Programme, through the ZikaPLAN consortium [734584]
- PSRC IRC in Early-Warning Sensing Systems for Infectious Diseases [EP/K031953/1]
- bioMerieux
- Sanofi Pasteur
- Takeda
- Foundation for Innovative and New Diagnostics
- World Health Organization (WHO) Special Program for Research and Training in Tropical Diseases
- WHO RD Blueprint
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI106695] Funding Source: NIH RePORTER
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Epidemics of dengue, Zika, and other arboviral diseases are increasing in frequency and severity. Current efforts to rapidly identify and manage these epidemics are limited by the short diagnostic window in acute infection, the extensive serologic cross-reactivity among flaviviruses, and the lack of point-of-care diagnostic tools to detect these viral species in primary care settings. The Partnership for Dengue Control organized a workshop to review the current landscape of Flavivirus diagnostic tools, identified current gaps, and developed strategies to accelerate the adoption of promising novel technologies into national programs. The rate-limiting step to bringing new diagnostic tools to the market is access to reference materials and well-characterized clinical samples to facilitate performance evaluation. We suggest the creation of an international laboratory-response consortium for flaviviruses with a decentralized biobank of well-characterized samples to facilitate assay validation. Access to proficiency panels are needed to ensure quality control, in additional to in-country capacity building.
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