Synthesis of methoxy poly(ethylene glycol)-b-poly(DL-lactide-co-glycolide) copolymer via diselenide linkage and fabrication of ebselen-incorporated nanoparticles for radio-responsive drug delivery

The ebselen has radio-protective effect. In this study, we investigate radio-protective effect of ebselen-incorporated nanoparticles using methoxy poly(ethylene glycol)-b-poly(m-lactide-co-glycolide) copolymer (LEsese). Ebselen-incorporated LEses nanoparticles were fabricated by nanoprecipitation and dialysis method. Their radio-protective effect was assessed under irradiation conditions in vitro and in vivo. The diameter was around 100 nm with spherical shapes. The ebselen release from nanoparticles was accelerated by irradiation dose. It compensated radiation damage against cells. Especially, ebselen-incorporated nanoparticles have superior radio-protective effects against animal's whole body irradiation trials. We suggest that LEsese nanoparticles are good candidate for radiation-responsive drug delivery and radioprotection application. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.