Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 46, Issue -, Pages 44-48Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2016.09.038
Keywords
Cadaverine; Bioconversion; Immobilization; Continuous production; Packed-bed reactor
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2015R1A2A2A04006014, NRF-2015M1A5A1037196]
- R&D Program of MOTIE/KEIT [10048350, 10047910]
- Korea Institute of Energy Technology Evaluation and Planning (KETEP)
- Ministry of Trade, Industry & Energy (MOTIE) of the Republic of Korea [20163010092150]
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Cadaverine, a five carbon diamine (1,5-diaminopentane), plays a role as a building block of polyamides and it can be made by fermentation or direct bioconversion. To improve its production by increasing reusability of immobilized enzyme and avoid separation of enzyme in bioconversion, a continuous l-lysine bioconversion process for cadaverine production has been developed. Various divalent cations, alginate concentrations, cell density with alginate and flow rate of feed were examined to maximize the lysine decarboxylase activity of the whole-cell immobilized beads. Under the selected conditions, 123 h of continuous cadaverine production has been performed and 5.5 L of 819 mM cadaverine were produced with 14 mL reactor resulting in 466.5 g of cadaverine. Cadaverine production was possible with small volume reactor maintaining relatively high concentration of substrate. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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