Advances in nanomicelles for sustained drug delivery

The efficient direct access of therapeutic molecules to the target tissues is still a major obstacle in developing useful therapeutic interventions. Over the past decades, polymeric micelles are interesting nanocarries for drug delivery systems due to small size (10-100 nm), low toxicity, capacity to solubilize lipophilic drugs in core and high drug loading. Here, the design of various nanomicelles such as amphiphilic dendrimer, boronate ester linked, X-shaped four-armed gemini-like, amphiphilic based vitamin E, styrene-maleic acid, diselenide linkages, oleic acid and natural polymeric inulin and vitamin E, siRNA and natural water soluble polysaccharides nanomicelles described and their efficacy discussed. (c) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.