Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 54, Issue -, Pages 262-269Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2017.06.001
Keywords
Bioavailability; Losartan; Microparticles; Mucoadhesion; Nanostructure
Funding
- grant of the Bio & Medical Technology Development Program of the National Research Foundation - Ministry of Science, ICT & Future Planning [2015M3A9E2030129]
- Basic Science Research Program through National Research Foundation of Korea(NRF) - Ministry of Science, ICT & Future Planning [2017R1A2B3004830]
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To enhance oral drug bioavailability, we propose mucoadhesive, nanostructured microparticles (PLGA/ PEG NM) as a drug-delivery vehicle. The PLGA/PEG NM herein retain nanofibrous structures within microparticles, and possess a seven-fold increase in specific surface area than conventional spherical microparticles, allowing for synergistic improvement of a mucoadhesive property. In vivo evaluations demonstrated that PLGA/PEG NM showed prolonged retention in the gastrointestinal tract, as compared to control microparticles. When PLGA/PEG NM was loaded with losartan, an oral anti-hypertension drug, drug's bioavailability increased by two-fold in comparison to a bolus losartan solution. Therefore, the PLGA/PEG NM are a promising carrier for oral drug delivery. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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