Journal
JOURNAL OF IMMUNOLOGY
Volume 198, Issue 10, Pages 3791-3800Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1602000
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Funding
- National Institutes of Health [AI123176, AI113125, AI115420]
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Activation of cells in the adaptive immune system is a highly orchestrated process dictated by multiples cues from the innate immune system. Although the fundamental principles of innate control of adaptive immunity are well established, it is not fully understood how innate cells integrate qualitative pathogenic information to generate tailored protective adaptive immune responses. In this review, we discuss complexities involved in the innate control of adaptive immunity that extend beyond TCR engagement, costimulation, and priming cytokine production but are critical for the generation of protective T cell immunity.
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