Journal
JOURNAL OF IMMUNOLOGY
Volume 198, Issue 8, Pages 3005-3014Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1601693
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Funding
- National Institutes of Health [R01 DK067180, R01 DK 098435, R01 DK100619, P30 DK42086]
- Research Council of Norway [179573/V40]
- European Commission [ERC-2010-Ad-268541]
- South-Eastern Norway Regional Health Authority
- Stiftelsen K.G. Jebsen
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Celiac disease is a human T cell-mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, this review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease.
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