Related references
Note: Only part of the references are listed.Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
Julio Gomez-Rodriguez et al.
NATURE COMMUNICATIONS (2016)
Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse
Alex T. Ritter et al.
IMMUNITY (2015)
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response
Yonglian Sun et al.
SCIENCE SIGNALING (2015)
T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens
Guillaume Voisinne et al.
CELL REPORTS (2015)
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response
Yonglian Sun et al.
SCIENCE SIGNALING (2015)
Interleukin-2-Inducible T-Cell Kinase (ITK) Deficiency - Clinical and Molecular Aspects
Sujal Ghosh et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2014)
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells
Julio Gomez-Rodriguez et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II
Xin Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
In the crosshairs: investigating lytic granules by high-resolution microscopy and electrophysiology
Varsha Pattu et al.
FRONTIERS IN IMMUNOLOGY (2013)
Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis
Fang Zhao et al.
IMMUNITY (2012)
IL-2-Inducible T-Cell Kinase Deficiency with Pulmonary Manifestations due to Disseminated Epstein-Barr Virus Infection
D. Mansouri et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2012)
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
David K. Finlay et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity
Patrick J. Shaw et al.
JOURNAL OF PHYSIOLOGY-LONDON (2012)
Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases
R. M. Linka et al.
LEUKEMIA (2012)
Two modes of lytic granule fusion during degranulation by natural killer cells
Dongfang Liu et al.
IMMUNOLOGY AND CELL BIOLOGY (2011)
IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function
Jordan S. Orange et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells
Emily J. Quann et al.
NATURE IMMUNOLOGY (2011)
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis
Andrea Maul-Pavicic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Itk Controls the Spatiotemporal Organization of T Cell Activation
Kentner L. Singleton et al.
SCIENCE SIGNALING (2011)
Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP
Umaimainthan Palendira et al.
PLOS BIOLOGY (2011)
Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets
Andrew D. Hislop et al.
BLOOD (2010)
The synapse and cytolytic machinery of cytotoxic T cells
Misty R. Jenkins et al.
CURRENT OPINION IN IMMUNOLOGY (2010)
Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases
Jan Rohr et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2010)
Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells
Matthew E. Pipkin et al.
IMMUNITY (2010)
T-Cell Signaling Regulated by the Tec Family Kinase, Itk
Amy H. Andreotti et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse
Misty R. Jenkins et al.
IMMUNITY (2009)
Differential Expression of Interleukin-17A and-17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase
Julio Gomez-Rodriguez et al.
IMMUNITY (2009)
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation
Kirsten Huck et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency
Andrew L. Snow et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells
Emily J. Quann et al.
NATURE IMMUNOLOGY (2009)
Selective Expression Rather than Specific Function of Txk and Itk Regulate Th1 and Th2 Responses
Nisebita Sahu et al.
JOURNAL OF IMMUNOLOGY (2008)
Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis
A. Santoro et al.
JOURNAL OF MEDICAL GENETICS (2006)
Centrosome polarization delivers secretory granules to the immunological synapse
Jane C. Stinchcombe et al.
NATURE (2006)
The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells
Luana O Atherly et al.
IMMUNITY (2006)
Innate immunity defects in Hennansky-Pudlak type 2 syndrome
Stefania Fontana et al.
BLOOD (2006)
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
S Feske et al.
NATURE (2006)
Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help
LO Atherly et al.
JOURNAL OF IMMUNOLOGY (2006)
Signals required for programming effector and memory development by CD8(+) T cells
Matthew F. Mescher et al.
IMMUNOLOGICAL REVIEWS (2006)
SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells
L Dupré et al.
BLOOD (2005)
Distinct role of lymphocyte fuinction-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes
N Anikeeva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton
D Dombroski et al.
JOURNAL OF IMMUNOLOGY (2005)
STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus
A O'Sullivan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative disease
R Sharifi et al.
BLOOD (2004)
Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)
J Feldmann et al.
CELL (2003)
Sensitive and viable identification of antigen-specific CD8+T cells by a flow cytometric assay for degranulation
MR Betts et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2003)
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP
CM Labno et al.
CURRENT BIOLOGY (2003)
Signal 3 determines tolerance versus full activation of naive CD8 T cells: Dissociating proliferation and development of effector function
JM Curtsinger et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
The regulation of actin remodeling during T-cell-APC conjugate formation
JL Cannon et al.
IMMUNOLOGICAL REVIEWS (2002)
Defective fas ligand expression and activation-induced cell death in the absence of IL-2-Inducible T cell kinase
AT Miller et al.
JOURNAL OF IMMUNOLOGY (2002)
The immunological synapse of CTL contains a secretory domain and membrane bridges
JC Stinchcombe et al.
IMMUNITY (2001)
Rab27a is required for regulated secretion in cytotoxic T lymphocytes
JC Stinchcombe et al.
JOURNAL OF CELL BIOLOGY (2001)
Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells
TR Malek et al.
JOURNAL OF IMMUNOLOGY (2001)
Share Paper
