Journal
JOURNAL OF IMMUNOLOGY
Volume 198, Issue 6, Pages 2223-2231Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1601629
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Funding
- intramural research programs of the National Institute of Diabetes and Digestive and Kidney Diseases
- Montreal Diabetes Research Center in collaboration with Diabete Quebec and by Fondation Lucie-Besner
- Fonds de Recherche en Sante du Quebec
- Natural Sciences and Engineering Research Council
- Cancer Research Society
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Immune tolerance is necessary to prevent the immune system from reacting against self, and thus to avoid the development of autoimmune diseases. In this review, we discuss key findings that position dendritic cells (DCs) as critical modulators of both thymic and peripheral immune tolerance. Although DCs are important for inducing both immunity and tolerance, increased auto-immunity associated with decreased DCs suggests their nonredundant role in tolerance induction. DC-mediated T cell immune tolerance is an active process that is influenced by genetic variants, environmental signals, as well as the nature of the specific DC subset presenting Ag to T cells. Answering the many open questions with regard to the role of DCs in immune tolerance could lead to the development of novel therapies for the prevention of autoimmune diseases.
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