Journal
JOURNAL OF IMMUNOLOGY
Volume 199, Issue 1, Pages 263-270Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1600409
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Funding
- National Institutes of Health (NIH) [R01 AI060025]
- NIH/National Institute of General Medical Sciences Ruth L. Kirschstein National Research Service Award [T32-CA-130807-08]
- Mizutani Foundation for Glycoscience Japan [150183]
- Bloomington Drosophila Stock Center through NIH [P40OD018537]
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Tracheal cytotoxin (TCT), a monomer of DAP-type peptidoglycan from Bordetella pertussis, causes cytopathology in the respiratory epithelia of mammals and robustly triggers the Drosophila Imd pathway. PGRP-LE, a cytosolic innate immune sensor in Drosophila, directly recognizes TCT and triggers the Imd pathway, yet the mechanisms by which TCT accesses the cytosol are poorly understood. In this study, we report that CG8046, a Drosophila SLC46 family transporter, is a novel transporter facilitating cytosolic recognition of TCT, and plays a crucial role in protecting flies against systemic Escherichia coli infection. In addition, mammalian SLC46A2s promote TCT-triggered NOD1 activation in human epithelial cell lines, indicating that SLC46As is a conserved group of peptidoglycan transporter contributing to cytosolic immune recognition.
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