Journal
JOURNAL OF HYPERTENSION
Volume 35, Issue 12, Pages 2479-2485Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0000000000001492
Keywords
atrophy; cerebrovascular disease; hypertension; hypertensive pregnancy; MRI; neuroimaging; preeclampsia
Categories
Funding
- [P50 AG044170]
- [R01 AG034676]
- [R01 AG040042]
- [R01 AG011378]
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Objective:Women with a history of preeclampsia are at an increased risk of hypertension and structural brain changes. However, the combined effect of both preeclampsia and late-life hypertension on brain structural changes is not known and was investigated in this study.Methods:Participants were identified from the population-based Rochester Epidemiology Project cohort. Four groups of women were recruited and investigated in this study: first, women with a history of normotensive pregnancy who have late-life hypertension (n=8, median age=62), second, women with a history of normotensive pregnancy who do not have late-life hypertension (n=32, median age=59), third, women with a history of preeclampsia who have late-life hypertension (n=24, median age=60), and fourth, women with a history of preeclampsia who do not have late-life hypertension (n=16, median age=57). Cerebrovascular disease lesions on MRI, and total gray matter volumes were assessed.Results:Total gray matter volumes were smaller in women with a history of preeclampsia and late-life hypertension compared with the other groups. Voxel-based morphometry demonstrated that the volume changes were localized to the posterior brain regions, particularly the occipital lobe gray matter in women with a history of preeclampsia and late-life hypertension.Conclusion:Having late-life hypertension superimposed on a history of preeclampsia affects the brain structure differently than having either a history of preeclampsia alone or a history of normotensive pregnancy either with or without late-life hypertension.
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