Journal
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
Volume 91, Issue 4, Pages -Publisher
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/0001-376520181077
Keywords
1,2-bis (2-thiazolin-2-isulfanyl) ethane; antimicrobial activity; hidrotris (2-mercaptothiazolyl) borate; complexes
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Funding
- Conselho Nacional de Desenvolvimento Cientifico Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Universidade Federal de Sao Joao Del-Rei (UFSJ)
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Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Grain-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 mu g/mL). Additionally, the compounds showed anti-Candida activity (MX values ranging from 250 to 500 mu g/mL), except the L1-Cr that was not active against any tested microorganism.
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