Journal
DEVELOPMENTAL DYNAMICS
Volume 245, Issue 3, Pages 209-219Publisher
WILEY
DOI: 10.1002/dvdy.24313
Keywords
lymphatic vasculature; morphogenesis; lymphatic vessels; progenitor cells; fate specification
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Funding
- NHMRC
- ARC
- SAHMRI Beat Cancer Project
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Lymphatic vessels serve crucial roles in the regulation of tissue fluid homeostasis, dietary lipid absorption and immune cell trafficking. Defects in lymphatic vessel morphogenesis and function have been associated with lymphedema, obesity, hypertension and tumour metastasis. Morphogenetic events important for construction of the lymphatic vasculature during development include the specification and emergence of lymphatic endothelial progenitor cells, their differentiation and assembly into interconnected vessels and vascular remodeling, ultimately giving rise to a functional vascular network. Despite the embryonic origins of lymphatic endothelial progenitor cells being long debated, work performed over the last decade had overwhelmingly supported at least a great majority of progenitor cells arising from the venous vasculature. Here, we review the most recent advances in the field of lymphatic vessel morphogenesis, with a focus on studies that have identified novel sources of embryonic lymphatic endothelial progenitor cells, together with the cellular mechanisms by which lymphatic vessels are initially assembled. Developmental Dynamics 245:209-219, 2016. (c) 2015 Wiley Periodicals, Inc.
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