Journal
GENERAL PHYSIOLOGY AND BIOPHYSICS
Volume 38, Issue 6, Pages 461-471Publisher
GENERAL PHYSIOL AND BIOPHYSICS
DOI: 10.4149/gpb_2019028
Keywords
LncRNA-ROR; miR-145; FLNB; EMT; Ovarian cancer
Categories
Funding
- National Natural Science Foundation of China [81702577]
- Natural Science Basic Research Program of Shaanxi [2018JQ8035]
- Fundamental Research Funds for the Central Universities [XZY012019105]
Ask authors/readers for more resources
Emerging evidence has indicated that long noncoding RNAs (LncRNAs) play critical roles in tumor development. LncRNA-regulator of reprogramming (ROR) could enhance the malignance of numerous tumors through promoting cell reprogramming and the chemoresistance of several cancers. Nevertheless, the detailed molecular mechanisms of LncRNA-ROR in ovarian cancer are not well elucidated. In our study, we demonstrated that LncRNA-ROR was high expression in ovarian cancer tissues than in normal ovarian tissues, and LncRNA-ROR level was positively associated with clinical stages and the differentiation grades of malignant cells. Functionally, LncRNA-ROR could induce epithelial-mesenchymal transition (EMT), and regulated ovarian cancer cell migration and invasion by decreasing the expression of tumor suppressive miR-145 and its target gene FLNB. Moreover, the binding site for miR-145 within LncRNA-ROR contributed to the reciprocal negative regulation of LncRNA-ROR and miR-145. Taken together, LncRNA-ROR promoted EMT by the miR-145/FLNB regulatory axis in ovarian cancer, providing a potential therapeutic target for ovarian cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available