Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 54, Issue 6, Pages 3241-3249Publisher
WILEY
DOI: 10.1002/jhet.2942
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New derivatives of 2,5-dimercapto-1,3,4-thiadiazole substituted both at one or two exocyclic sulfur atoms with a series of aroyl or ethoxycarbonyl groups were synthesized in reactions of 2,5-dimercapto-1,3,4-thiadiazole salts with appropriate acid chlorides or ethyl chloroformate in mild conditions. The products were characterized by spectroscopy (H-1 NMR, C-13 NMR, IR, and HRMS). Some from the synthesized compounds were screened in vitro and in vivo for antibacterial and antifungal activities against a panel of reference strains of microorganisms. The study revealed that ethyl S-(5-mercapto-1,3,4-thiadiazol-2-y1) carbonothioate seems to he the most active and versatile compound against Gram-positive bacteria, Gram-negative bacteria, and plant pathogenic fungi.
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