Survey Reactivity of Some Substituted Quinazolinones with Pentafluoro(chloro)pyridine

A new series of 4-hetroaryl substituted quinazolines were designed and synthesized by the reaction of pentafluoro(chloro)pyridine and 2-substituted quinazolinone. The aromatic nucleophilic substitution of pentafluoro(chloro)pyridine with quinazolinone occurs at the 4-position of pyridine ring by the oxygen site (O-centered nucleophile) of quinazolinone. The structures of all the compounds were confirmed by IR, H-1 NMR, F-19 NMR, and C-13 NMR spectroscopy as well as elemental analysis.