4.7 Article

Insights into the κ/ι-carrageenan metabolism pathway of some marine Pseudoalteromonas species

Journal

COMMUNICATIONS BIOLOGY
Volume 2, Issue 1, Pages -

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/s42003-019-0721-y

Keywords

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Funding

  1. Natural Sciences and Engineering Research Council of Canada [FRN 04355]
  2. Natural Sciences and Engineering Research Council of Canada
  3. National Research Council Canada
  4. Canadian Institutes of Health Research
  5. Province of Saskatchewan
  6. Western Economic Diversification Canada
  7. University of Saskatchewan
  8. U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-76SF00515]
  9. DOE Office of Biological and Environmental Research
  10. National Institutes of Health, National Institute of General Medical Sciences [P41GM103393]

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Pseudoalteromonas is a globally distributed marine-associated genus that can be found in a broad range of aquatic environments, including in association with macroalgal surfaces where they may take advantage of these rich sources of polysaccharides. The metabolic systems that confer the ability to metabolize this abundant form of photosynthetically fixed carbon, however, are not yet fully understood. Through genomics, transcriptomics, microbiology, and specific structure-function studies of pathway components we address the capacity of newly isolated marine pseudoalteromonads to metabolize the red algal galactan carrageenan. The results reveal that the kappa/iota-carrageenan specific polysaccharide utilization locus (CarPUL) enables isolates possessing this locus the ability to grow on this substrate. Biochemical and structural analysis of the enzymatic components of the CarPUL promoted the development of a detailed model of the kappa/iota-carrageenan metabolic pathway deployed by pseudoalteromonads, thus furthering our understanding of how these microbes have adapted to a unique environmental niche.

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