Journal
STEM CELL REVIEWS AND REPORTS
Volume 15, Issue 6, Pages 866-879Publisher
SPRINGER
DOI: 10.1007/s12015-019-09911-5
Keywords
Oncogene; PTTG1; Securin; Cancer stem cells; Ovary; Stem cells; Ovarian cancer
Funding
- NCI NIH HHS [UO1CA2177798] Funding Source: Medline
- NHLBI NIH HHS [T32 HL134644] Funding Source: Medline
- NIH HHS [T32HL134644] Funding Source: Medline
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Origin of cancer stem cells (CSCs) and mechanisms by which oncogene PTTG1 contributes to tumor progression via CSCs is not known. Ovarian CSCs exhibit characteristics of self-renewal, tumor-initiation, growth, differentiation, drug resistance, and tumor relapse. A common location of putative origin, namely the ovarian surface epithelium, is shared between the normal stem and CSC compartments. Existence of ovarian stem cells and their co-expression with CSC signatures suggests a strong correlation between origin of epithelial cancer and CSCs. We hereby explored a putative oncogene PTTG1 (Securin), reported to be overexpressed in various tumors, including ovarian. We report a previously overlooked role of PTTG1 as a marker of CSCs thereby modulating CSC, germline, and stemness-related genes. We further characterized PTTG1's ability to regulate (cancer) stem cell-associated self-renewal and epithelial-mesenchymal transition pathways. Collectively, the data sheds light on a potential target expressed during ovarian tumorigenesis and metastatically disseminated ascites CSCs in the peritoneal cavity. Present study highlights this unconventional, under-explored role of PTTG1 in regulation of stem and CSC compartments in ovary, ovarian cancer and ascites and highlights it as a potential candidate for developing CSC specific targeted therapeutics.
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