Journal
JOURNAL OF HEPATOLOGY
Volume 66, Issue 6, Pages 1313-1326Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhep.2017.01.006
Keywords
Anticoagulation; Thrombosis; Cirrhosis; Heparin; Direct oral anticoagulants; Thromboembolism; Liver diseases; Teaching rounds
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Funding
- National Institute of Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust
- Imperial College London
- National Institute for Health Research [ACF-2012-21-004] Funding Source: researchfish
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In this Grand Round presentation, the case of a man with decompensated liver disease is described. He subsequently developed a fatal pulmonary embolism, which may not have occurred if he had been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. The burden of thrombotic disease in those with chronic liver disease is discussed, before a more detailed analysis of the current evidence, safety data, and clinical dilemmas regarding the use of anticoagulation in patients with chronic liver disease. Finally, the future directions within this field are explored. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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