Journal
JOURNAL OF HEPATOLOGY
Volume 67, Issue 3, Pages 603-618Publisher
ELSEVIER
DOI: 10.1016/j.jhep.2017.04.009
Keywords
Hepatocellular carcinoma; HCC; Long non; coding RNA; lncRNA; microRNA; Liver cancer; STAT3; Wnt; Epithelial-to-mesenchymal transition; Cancer stem cell
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Funding
- Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS)
- Deutsche Forschungsgemeinschaft [DFG Di 1421/7-1, EXC81, SFB 850]
- Office of the NIH Director Common Fund Program through the National Center for Advancing Translational Sciences [UH3 TR00884]
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The majority of the human genome is not translated into proteins but can be transcribed into RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins, they contribute to diseases such as cancer. Here, we review examples of the functions of ncRNAs in liver cancer and their potential use for the detection and treatment of liver cancer. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
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