Journal
DEVELOPMENTAL BIOLOGY
Volume 403, Issue 1, Pages 80-88Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2015.04.008
Keywords
Mouse; Embryo; Wnt3; Gastrulation; Primitive streak; Axial specification
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Funding
- NIH [GM87130, GM94874, HD052115, DK084391]
- Ben F. Love Endowment
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Brazil [200961/2008]
- NIH Cancer Center Support (Core) Grant [CA16672]
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The establishment of the head to tail axis at early stages of development is a fundamental aspect of vertebrate embryogenesis. In mice, experimental embryology, genetics and expression studies have suggested that the visceral endoderm, an extra-embryonic tissue, plays an important role in anteroposterior axial development. Here we show that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between anterior and posterior visceral endoderm restricts the position of the primitive streak. Embryos lacking Wnt3 in the visceral endoderm, however, appear normal by E9.5. Our results suggest a model for axial development in which multiple signals are required for anteroposterior axial development in mammals. (C) 2015 Elsevier Inc. All rights reserved.
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