Journal
JOURNAL OF RHEUMATIC DISEASES
Volume 26, Issue 3, Pages 165-178Publisher
KOREAN COLL RHEUMATOLOGY
DOI: 10.4078/jrd.2019.26.3.165
Keywords
Myositis; Dermatomyositis; Polymyositis; Antinuclear antibody
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Funding
- Basic Science Research Program through the NRF - Ministry of Education [NRF-2018R1D1A1B07043681]
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Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune muscle diseases with systemic involvement. Patients with IIM present with varying degrees of muscle disease, cutaneous manifestations, and internal organ involvement. The diagnosis and classification of IIM is based primarily on the classification system composed of clinical features, laboratory value and muscle biopsy. In addition, the identification and characterization of myositis-related autoantibodies can help diagnosis and classification. Recently, many studies have also demonstrated that the physician can define the clinical syndromes, establish treatment strategy and predict outcomes based on the patients' myositis-specific autoantibodies (MSA) and myositis-associated antibodies (MAA) profiles. MSAs are found exclusively in IIMs and facilitate the identification of subsets of patients with relatively homogeneous clinical features. MAAs are frequently found in association with other MSA; however, they may also be detected in various connective diseases.
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