Journal
NANOTECHNOLOGY REVIEWS
Volume 8, Issue 1, Pages 548-561Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/ntrev-2019-0049
Keywords
Phenylboronic acid; Polymeric nanomaterials; Polyols; Drug delivery
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Funding
- Guizhou Provincial Department of Education Youth Science and Technology Talent Development Project [[2018]150]
- Doctoral Foundation of Guizhou Medical University [JY2017-28]
- Science and Technology Department of Guizhou Province, Guizhou Branch of Talent Gund [[2017]5718]
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The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bioapplication has beenwell established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.
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