Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 327, Issue -, Pages 180-186Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2016.12.040
Keywords
Genotoxicity; Zinc oxide nanoparticles; Drosophila melanogaster; Risk assessment; Nanotoxicology
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Funding
- DRDO,Govt of India [DIP-259]
- Department of Science and Technology, New Delhi
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Zinc oxide nanoparticles (ZnO NPs) are commonly used nanomaterials (NMs) with versatile applications from high-end technologies to household products. This pervasive utilisation has brought human in the close interface with nanoparticles (NPs), hence questioning their safety prior to usage is a must. In this study, we have assessed the effects of chronic exposure to ZnO NPs (<50 nm) on the model organism Drosophila melanogaster. Potential toxic effects were studied by evaluating longevity, climbing ability, oxidative stress and DNA fragmentation. Ensuing exposure, the FO (parent), F1, F2, F3 and F4 generation flies were screened for the aberrant phenotype. Flies exposed to ZnO NPs showed distinctive phenotypic changes, like deformed segmented thorax and single or deformed wing, which were transmitted to the offspring's in subsequent generations. The unique abnormal phenotype is evident of chronic toxicity induced by ZnO NPs, although appalling, it strongly emphasize the importance to understand NPs toxicity for safer use. (C) 2016 Elsevier B.V. All rights reserved.
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