Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 57, Issue 3, Pages 200-208Publisher
WILEY-BLACKWELL
DOI: 10.1111/dgd.12194
Keywords
electroporation; macaque; marmoset; mouse; primary culture
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Funding
- NBRP Japanese Monkeys through the National Bio-Resource Project of the MEXT, Japan
- JSPS KAKENHI [25750403]
- Takeda Science Foundation
- JSPS through the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program), - initiated by the Council for Science and Technology Policy (CSTP)
- Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) by the MEXT of Japan
- Grants-in-Aid for Scientific Research [25750403] Funding Source: KAKEN
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Periostin (POSTN or osteoblast specific factor) is an extracellular matrix protein originally identified as a protein highly expressed in osteoblasts. Recently, periostin has been reported to function in axon regeneration and neuroprotection. In the present study, we focused on periostin function in cortical evolution. We performed a comparative gene expression analysis of periostin between rodents (mice) and primates (marmosets and macaques). Periostin was expressed at higher levels in the primate cerebral cortex compared to the mouse cerebral cortex. Furthermore, we performed overexpression experiments of periostin invivo and invitro. Periostin exhibited neurite outgrowth activity in cortical neurons. These results suggested the possibility that prolonged and increased periostin expression in the primate cerebral cortex enhances the cortical plasticity of the mammalian cerebral cortex.
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