Journal
DEVELOPMENT
Volume 143, Issue 3, Pages 516-529Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.129957
Keywords
Neurogenesis; Tal1; Gata2; Gata3; Transcription factor; VTA; SNpr; RMTg; GABA; Glutamate; Dopamine; Serotonin; Midbrain; Hindbrain; Mouse; Chicken
Categories
Funding
- Academy of Finland
- Sigrid Juselius Foundation
- University of Helsinki
- Center for International Mobility (CIMO)
- Otto A. Malm foundation
- Integrative Life Sciences doctoral program
- Ella and Georg Ehrnrooth Foundation
- Jane and Aatos Erkko Foundation
Ask authors/readers for more resources
Local inhibitory GABAergic and excitatory glutamatergic neurons are important for midbrain dopaminergic and hindbrain serotonergic pathways controlling motivation, mood, and voluntary movements. Such neurons reside both within the dopaminergic nuclei, and in adjacent brain structures, including the rostromedial and laterodorsal tegmental nuclei. Compared with the monoaminergic neurons, the development, heterogeneity, and molecular characteristics of these regulatory neurons are poorly understood. We show here that different GABAergic and glutamatergic subgroups associated with the monoaminergic nuclei express specific transcription factors. These neurons share common origins in the ventrolateral rhombomere 1, where the postmitotic selector genes Tal1, Gata2 and Gata3 control the balance between the generation of inhibitory and excitatory neurons. In the absence of Tal1, or both Gata2 and Gata3, the GABAergic precursors adopt glutamatergic fates and populate the glutamatergic nuclei in excessive numbers. Together, our results uncover developmental regulatory mechanisms, molecular characteristics, and heterogeneity of central regulators of monoaminergic circuits.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available