Journal
DEVELOPMENT
Volume 142, Issue 19, Pages 3253-3262Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.127878
Keywords
Apoptosis; Morphogenesis; Signaling; Tissue remodeling; Silent mechanism of cell elimination
Categories
Funding
- National Institutes of Health [RO1GM60124]
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Apoptosis, in contrast to other forms of cell death such as necrosis, was originally regarded as a 'silent' mechanism of cell elimination designed to degrade the contents of doomed cells. However, during the past decade it has become clear that apoptotic cells can produce diverse signals that have a profound impact on neighboring cells and tissues. For example, apoptotic cells can release factors that influence the proliferation and survival of adjacent tissues. Apoptosis can also affect tissue movement and morphogenesis by modifying tissue tension in surrounding cells. As we review here, these findings reveal unexpected roles for apoptosis in tissue remodeling during development, as well as in regeneration and cancer.
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