Journal
JOURNAL OF GENERAL VIROLOGY
Volume 98, Issue 10, Pages 2413-2420Publisher
MICROBIOLOGY SOC
DOI: 10.1099/jgv.0.000908
Keywords
Tembusu virus; virus genome characteristics; host range; transmission; host innate immune response; vaccine
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Funding
- National Key RD Program [2016YFD0500800]
- China Agricultural Research System [CARS-43-8]
- National Science and Technology Support Program [2015BAD12N05]
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Tembusu virus (TMUV, genus Flavivirus, family Flaviviridae) was first isolated in 1955 from Culex tritaeniorhynchus mosquitoes in Kuala Lumpur, Malaysia. In April 2010, duck TMUV was first identified as the causative agent of egg-drop syndrome, characterized by a substantial decrease in egg laying and depression, growth retardation and neurological signs or death in infected egg-laying and breeder ducks, in the People's Republic of China. Since 2010, duck TMUV has spread to most of the duck-producing regions in China, including many of the coastal provinces, neighbouring regions and certain Southeast Asia areas (i.e. Thailand and Malaysia). This review describes the current understanding of the genome characteristics, host range, transmission, epidemiology, phylogenetic and immune evasion of avian-origin TMUV and the innate immune response of the host.
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