Journal
PHARMACEUTICAL BIOLOGY
Volume 57, Issue 1, Pages 807-816Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13880209.2019.1693605
Keywords
Flavonoid; blood lipid; blood glucose; oxidative stress; streptozotocin
Funding
- GuangXi Key Laboratory of Zhuang and Yao Ethnic Medicine [Guikejizi[2014]32]
- Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine [Guijiaokeyan[2013]20]
- Guangxi first-class discipline of traditional Chinese medicine (ethnic medicine) [Guijiaokeyan[2018]12]
- GuangXi Key Discipline (Zhuang Ethnic Medicine) [Guijiaokeyan[2013]16]
- Guangxi special experts project [Guirencaitongzi[2019]13]
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Context: Melastoma dodecandrum Lour. (Melastomataceae) is a traditional Chinese medicine. This is the first study to report a protective effect of the ethanol extract from M. dodecandrum (MDE) in type 2 diabetic (T2DM) rats. Objective: To investigate the therapeutic mechanism of MDE in T2DM rats. Materials and methods: Sprague-Dawley rats were fed a high-fat diet for 6 consecutive weeks, followed by intraperitoneal injection of streptozotocin (STZ) (30mg/kg) to induce diabetes. T2DM rats were divided into untreated diabetic, metformin-treated and MDE-treated groups. Additionally, normal rats without treatment served as the control group (n = 6). Metformin (250mg/kg) and MDE (600mg/kg) were intragastrically administered to T2DM rats for 5 consecutive weeks. Serum samples were evaluated via ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS), followed by principal components analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). Results: The 17 identified potential biomarkers were mainly involved in lipid, amino acid, arachidonic acid, taurine and nicotinic acid metabolism. MDE also significantly reduced the level of fasting blood glucose (FBG), oral glucose tolerance, insulin, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and urea nitrogen (BUN) in T2DM rats. The high-density lipoprotein (HDL), serum creatinine (Scr), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) levels were elevated in MDE-treated group. Discussion and conclusion: MDE possesses substantial antidiabetic activity, especially in lipid disorder regulation. This suggests that the use of MDE can be generalized to broader pharmacological studies, such as obesity and hyperlipidaemia.
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