Journal
ADVANCES IN MICROSCOPIC IMAGING II
Volume 11076, Issue -, Pages -Publisher
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2527214
Keywords
Light Sheet Fluorescence Microscopy (LSFM); Multicellular tumor spheroids (MCTS); drug screening and individualized therapy; Glioblastoma Brain cancer; Breast cancer
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Funding
- project BIOIMAGING-GR [MIS5002755]
- project HELLAS-CH [MIS 5002735]
- Operational Programme Competitiveness, Entrepreneurship and Innovation (NSRF 2014-2020)
- European Union (European Regional Development Fund)
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Breast cancer and Glioblastoma brain cancer are aggressive malignancies with poor prognosis. In this study primary Glioblastoma and secondary breast cancer spheroids are formed and treated with the well-known Temozolomide and Doxorubicin chemotherapeutics, respectively. A custom multi-angle Light Sheet Fluorescence Microscope is employed for high resolution imaging of both cancer cell spheroids. Such a technique is successful in realizing pre-clinical drug screening, while enables the discrimination among physiologic tumor parameters. LSFM technique, parameters and method followed are also presented.
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